A respected documentary maker hears from a friend that his long term depression has been helped after watching a video entitled "Food matters" and following a nutritional protocol involving high doses of vitamins, as outlined by a featured speaker in Foodmatters, by the name of Andrew W Saul. Beatie visits Saul and is given an outline of Orthomolecular Medicine, the protocol envisaged by Nobel prize winners and eminent scientists.

Why are so many people wheat-intolerant or sensitive to wheat? And why is wheat linked to so many modern-day health problems, when it has been a staple of the human diet for thousands of years? In this documentary, a nutritionist interviews 14 experts, to understand how wheat has changed since it was first cultivated, how these changes could be affecting human health, and how people can break a dietary cycle that could be making them sick.